Runx2 Protein Represses Axin2 Expression in Osteoblasts and Is Required for Craniosynostosis in Axin2-deficient Mice

Runx2 and Axin2 regulate craniofacial development and skeletal maintenance. Runx2 is essential for calvarial bone development, as Runx2 haploinsufficiency causes cleidocranial dysplasia. In contrast, Axin2-deficient mice develop craniosynostosis because of high β-catenin activity. Axin2 levels are e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: McGee-Lawrence, Meghan E., Li, Xiaodong, Bledsoe, Krista L., Wu, Hai, Hawse, John R., Subramaniam, Malayannan, Razidlo, David F., Stensgard, Bridget A., Stein, Gary S., van Wijnen, Andre J., Lian, Jane B., Hsu, Wei, Westendorf, Jennifer J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2013
Aiheet:
Gene Regulation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581413/
https://ncbi.nlm.nih.gov/pubmed/23300083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414995
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