Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases

Histone deacetylase 4 (HDAC4) and its paralogs, HDAC5, -7, and -9 (all members of class IIa), possess multiple phosphorylation sites crucial for 14-3-3 binding and subsequent nuclear export. cAMP signaling stimulates nuclear import of HDAC4 and HDAC5, but the underlying mechanisms remain to be eluci...

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Main Authors: Walkinshaw, Donald R., Weist, Ryan, Xiao, Lin, Yan, Kezhi, Kim, Go-Woon, Yang, Xiang-Jiao
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581380/
https://ncbi.nlm.nih.gov/pubmed/23297420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445668
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