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Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import

Chromatin remodeling by histone deacetylases (HDACs), is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic-adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Taniguchi, Makoto, Carreira, Maria B., Smith, Laura N., Zirlin, Benjamin C., Neve, Rachael L., Cowan, Christopher W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259532/
https://ncbi.nlm.nih.gov/pubmed/22243750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.10.032
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