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Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import
Chromatin remodeling by histone deacetylases (HDACs), is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic-adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259532/ https://ncbi.nlm.nih.gov/pubmed/22243750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.10.032 |
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