Protease-activated Receptor 2 (PAR(2)) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential (TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated receptor 2 (PAR(2)), a receptor for inflammatory proteases, is a major mediator of neurogenic inflammation and pain. We...

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Autori principali: Poole, Daniel P., Amadesi, Silvia, Veldhuis, Nicholas A., Abogadie, Fe C., Lieu, TinaMarie, Darby, William, Liedtke, Wolfgang, Lew, Michael J., McIntyre, Peter, Bunnett, Nigel W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581372/
https://ncbi.nlm.nih.gov/pubmed/23288842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438184
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