Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs

INTRODUCTION: Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis. However, patients with severe metformin intoxication may have a 30 to 60% decrease in their global oxygen consumption, as for generalized inhibition of mitochondrial res...

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Autori principali: Protti, Alessandro, Fortunato, Francesco, Monti, Massimo, Vecchio, Sarah, Gatti, Stefano, Comi, Giacomo P, De Giuseppe, Rachele, Gattinoni, Luciano
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580617/
https://ncbi.nlm.nih.gov/pubmed/22568883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc11332
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