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Succinate and the shortcut to the cure of metformin-induced lactic acidosis

Inhibition of the respiratory chain complex I plays a key role in the pathogenesis of metformin-induced lactic acidosis. In a work recently published in this journal, a novel cell-permeable succinate prodrug (NV118) increased in vitro mitochondrial oxygen consumption coupled with energy production a...

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Bibliografische gegevens
Gepubliceerd in:Intensive Care Med Exp
Hoofdauteur: Protti, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153199/
https://ncbi.nlm.nih.gov/pubmed/30251134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-018-0202-5
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