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Succinate and the shortcut to the cure of metformin-induced lactic acidosis
Inhibition of the respiratory chain complex I plays a key role in the pathogenesis of metformin-induced lactic acidosis. In a work recently published in this journal, a novel cell-permeable succinate prodrug (NV118) increased in vitro mitochondrial oxygen consumption coupled with energy production a...
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| Veröffentlicht in: | Intensive Care Med Exp |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153199/ https://ncbi.nlm.nih.gov/pubmed/30251134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-018-0202-5 |
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