Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

INTRODUCTION: Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction. To verify this hypothesis, we investigated whether body oxygen consumption (VO(2)), that primarily depends on mitochondrial respiration, is depr...

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Main Authors: Protti, Alessandro, Russo, Riccarda, Tagliabue, Paola, Vecchio, Sarah, Singer, Mervyn, Rudiger, Alain, Foti, Giuseppe, Rossi, Anna, Mistraletti, Giovanni, Gattinoni, Luciano
格式: Artigo
語言:Inglês
出版: BioMed Central 2010
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Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875537/
https://ncbi.nlm.nih.gov/pubmed/20170489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8885
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