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Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases
Acetylation of the tumor suppressor gene p53 at the carboxy-terminal lysine (Lys) residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis. Histone deacetylases (HDACs), a family of evolutionarily conserved enzymes, counterbalance the acetylation of lysine resid...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3580388/ https://ncbi.nlm.nih.gov/pubmed/22552582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2012.1449 |
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