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Interleukin-4 Inhibits RANKL-Induced NFATc1 Expression Via STAT6: A Novel Mechanism Mediating its Blockade of Osteoclastogenesis
Interleukin-4 (IL-4) is an important immune regulatory protein that possesses potent anti-osteoclastogenic properties, and does so via the transcription factor STAT6. Previous studies have shown that IL-4 selectively blocks RANKL-induced activation of NF-κB and mitogen-activated protein kinase (MAPK...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3580163/ https://ncbi.nlm.nih.gov/pubmed/21751242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23269 |
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