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AKAP-dependent sensitization of Ca(v)3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2)-induced mechanical hyperalgesia
BACKGROUND AND PURPOSE: The Ca(v)3.2 isoform of T-type Ca(2+) channels (T channels) is sensitized by hydrogen sulfide, a pro-nociceptive gasotransmitter, and also by PKA that mediates PGE(2)-induced hyperalgesia. Here we examined and analysed Ca(v)3.2 sensitization via the PGE(2)/cAMP pathway in NG1...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Blackwell Publishing Ltd
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579291/ https://ncbi.nlm.nih.gov/pubmed/22924591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02174.x |
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