AKAP-dependent sensitization of Ca(v)3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2)-induced mechanical hyperalgesia

BACKGROUND AND PURPOSE: The Ca(v)3.2 isoform of T-type Ca(2+) channels (T channels) is sensitized by hydrogen sulfide, a pro-nociceptive gasotransmitter, and also by PKA that mediates PGE(2)-induced hyperalgesia. Here we examined and analysed Ca(v)3.2 sensitization via the PGE(2)/cAMP pathway in NG1...

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Detalhes bibliográficos
Main Authors: Sekiguchi, Fumiko, Aoki, Yuka, Nakagawa, Maiko, Kanaoka, Daiki, Nishimoto, Yuta, Tsubota-Matsunami, Maho, Yamanaka, Rumi, Yoshida, Shigeru, Kawabata, Atsufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579291/
https://ncbi.nlm.nih.gov/pubmed/22924591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02174.x
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