Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats

BACKGROUND AND PURPOSE: High-mobility group box 1 (HMGB1), a nuclear protein, is actively or passively released during inflammation. Recombinant human soluble thrombomodulin (rhsTM), a medicine for treatment of disseminated intravascular coagulation (DIC), sequesters HMGB1 and promotes its degradati...

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Detalhes bibliográficos
Main Authors: Tanaka, Junichi, Seki, Yukari, Ishikura, Hiroyasu, Tsubota, Maho, Sekiguchi, Fumiko, Yamaguchi, Kaoru, Murai, Akira, Umemura, Takehiro, Kawabata, Atsufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838698/
https://ncbi.nlm.nih.gov/pubmed/24004409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12396
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