Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H(2)S/Ca(v)3.2 Signaling in Mice

Cystitis-related bladder pain involves RAGE activation by HMGB1, and increased Ca(v)3.2 T-type Ca(2+) channel activity by H(2)S, generated by upregulated cystathionine-γ-lyase (CSE) in mice treated with cyclophosphamide (CPA). We, thus, investigated possible crosstalk between the HMGB1/RAGE and CSE/...

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Veröffentlicht in:Cells
Hauptverfasser: Hiramoto, Shiori, Tsubota, Maho, Yamaguchi, Kaoru, Okazaki, Kyoko, Sakaegi, Aya, Toriyama, Yuki, Tanaka, Junichi, Sekiguchi, Fumiko, Ishikura, Hiroyasu, Wake, Hidenori, Nishibori, Masahiro, Nguyen, Huy Du, Okada, Takuya, Toyooka, Naoki, Kawabata, Atsufumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463894/
https://ncbi.nlm.nih.gov/pubmed/32707767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9081748
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