Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Ca(v)3.2 and TRPA1 channels in mice

BACKGROUND AND PURPOSE: Hydrogen sulfide, a gasotransmitter, facilitates somatic pain signals via activation of Ca(v)3.2 T-type calcium channels in rats. Given evidence for the activation of transient receptor potential ankyrin-1 (TRPA1) channels by H(2)S, we asked whether TRPA1 channels, in additio...

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Detalhes bibliográficos
Main Authors: Okubo, Kazumasa, Matsumura, Midori, Kawaishi, Yudai, Aoki, Yuka, Matsunami, Maho, Okawa, Yasumasa, Sekiguchi, Fumiko, Kawabata, Atsufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419915/
https://ncbi.nlm.nih.gov/pubmed/22300342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01886.x
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