Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

Cav3.2, a T-type calcium channel (T-channel) family member, is expressed in the nociceptors and spinal cord, and its activity is largely suppressed by zinc under physiological conditions. In rats, intrathecal and intraplantar administration of a zinc chelator, TPEN, caused T-channel-dependent mechan...

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Hlavní autoři:	Shiori Tomita, Fumiko Sekiguchi, Katsuki Naoe, Shiyu Shikimi, Yoshihito Kasanami, Maya Ohigashi, Maho Tsubota, Atsufumi Kawabata
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-06-01
Edice:	Journal of Pharmacological Sciences
Témata:	Cav3.2 T-type calcium channel Pain Hyperalgesia Zinc deficiency TPEN
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S134786132300021X
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