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Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation

A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex. Three mRNA splice variants are expressed, but only one is expressed as a protein, although at lower levels than the WT NCF1 (also known as p47phox). Our aim was to investigate whether the mutant...

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Bibliografiske detaljer
Main Authors: Sareila, Outi, Jaakkola, Noora, Olofsson, Peter, Kelkka, Tiina, Holmdahl, Rikard
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579024/
https://ncbi.nlm.nih.gov/pubmed/23271700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1211588
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