High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells

Defects in T-cell function in patients with cancer might influence their capacity to mount efficient antitumor immune responses. Here, we identified highly reduced IL-4–, IL-10–, and IL-21–induced phosphorylation of STAT6 and STAT3 in tumor-infiltrating T cells (TILs) in follicular lymphoma (FL) tum...

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Detalhes bibliográficos
Main Authors: Myklebust, June H., Irish, Jonathan M., Brody, Joshua, Czerwinski, Debra K., Houot, Roch, Kohrt, Holbrook E., Timmerman, John, Said, Jonathan, Green, Michael R., Delabie, Jan, Kolstad, Arne, Alizadeh, Ash A., Levy, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578953/
https://ncbi.nlm.nih.gov/pubmed/23297127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-421826
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