Live Attenuated Leishmania donovani p27 Gene Knockout Parasites Are Non-pathogenic and Elicit Long Term Protective Immunity in BALB/c Mice

Leishmaniasis causes significant morbidity and mortality worldwide and there are no vaccines available against this disease. Previously, we had shown that the amastigote specific protein p27 (Ldp27) is a component of an active cytochrome c oxidase complex in L. donovani and upon deletion of its gene...

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Autori principali: Dey, Ranadhir, Dagur, Pradeep K., Selvapandiyan, Angamuthu, McCoy, J. Philip, Salotra, Poonam, Duncan, Robert, Nakhasi, Hira L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578143/
https://ncbi.nlm.nih.gov/pubmed/23338240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202801
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