Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

Currently no effective vaccine is available for human visceral leishmaniasis(VL) caused by Leishmania donovani. Previously, we showed that centrin1 and p27gene deleted live attenuated Leishmania parasites (LdCen1(−/−) and Ldp27(−/−)) are safe, immunogenic and protective in animal models. Here, to as...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Avishek, Kumar, Kaushal, Himanshu, Gannavaram, Sreenivas, Dey, Ranadhir, Selvapandiyan, Angamuthu, Ramesh, V., Negi, Narender Singh, Dubey, Uma S., Nakhasi, Hira L., Salotra, Poonam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021981/
https://ncbi.nlm.nih.gov/pubmed/27624408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33059
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