Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

Currently no effective vaccine is available for human visceral leishmaniasis(VL) caused by Leishmania donovani. Previously, we showed that centrin1 and p27gene deleted live attenuated Leishmania parasites (LdCen1(−/−) and Ldp27(−/−)) are safe, immunogenic and protective in animal models. Here, to as...

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Publicado en:Sci Rep
Main Authors: Avishek, Kumar, Kaushal, Himanshu, Gannavaram, Sreenivas, Dey, Ranadhir, Selvapandiyan, Angamuthu, Ramesh, V., Negi, Narender Singh, Dubey, Uma S., Nakhasi, Hira L., Salotra, Poonam
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021981/
https://ncbi.nlm.nih.gov/pubmed/27624408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33059
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