SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells

PURPOSE: Human leukocyte antigen (HLA) class I antigen processing machinery (APM) component downregulation permits escape of malignant cells from recognition by cytotoxic T lymphocytes (CTL) and correlates with poor prognosis in patients with head and neck cancer (HNC). Activated STAT1 (pSTAT1) is n...

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Main Authors: Leibowitz, Michael S., Srivastava, Raghvendra M., Filho, Pedro A. Andrade, Egloff, Ann Marie, Wang, Lin, Seethala, Raja R., Ferrone, Soldano, Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578140/
https://ncbi.nlm.nih.gov/pubmed/23363816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1517
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