STAT1-Induced HLA class I Upregulation Enhances Immunogenicity and Clinical Response to anti-EGFR mAb Cetuximab Therapy in HNC Patients

The goal of this study was to characterize the molecular mechanisms underlying cetuximab-mediated upregulation of HLA class I antigen-processing machinery components in head and neck cancer (HNC) cells and to determine the clinical significance of these changes in cetuximab-treated HNC patients. Flo...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Srivastava, Raghvendra M., Trivedi, Sumita, Concha-Benavente, Fernando, Hyun-bae, Jie, Wang, Lin, Seethala, Raja R., Branstetter, Barton F., Ferrone, Soldano, Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526378/
https://ncbi.nlm.nih.gov/pubmed/25972070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0053
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