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Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes

Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM com...

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Detalhes bibliográficos
Main Authors: Leibowitz, Michael S., Filho, Pedro A. Andrade, Ferrone, Soldano, Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426276/
https://ncbi.nlm.nih.gov/pubmed/21207025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-010-0961-7
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