Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors()

The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN responses. It is known that plasmacytoid dendritic cells sense herpesvirus DNA in endosomes via TLR9, and that non-immune tissue cells can sense herp...

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Detalhes bibliográficos
Main Authors: Horan, Kristy A., Hansen, Kathrine, Jakobsen, Martin R., Holm, Christian K., Søby, Stine, Unterholzner, Leonie, Thompson, Mikayla, West, John A., Iversen, Marie B., Rasmussen, Simon B., Ellermann-Eriksen, Svend, Kurt-Jones, Evelyn, Landolfo, Santo, Damania, Blossom, Melchjorsen, Jesper, Bowie, Andrew G., Fitzgerald, Katherine A., Paludan, Søren R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578088/
https://ncbi.nlm.nih.gov/pubmed/23345332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202749
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