Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways

Innate recognition of viruses is mediated by pattern recognition receptors (PRRs) triggering expression of antiviral interferons (IFNs) and proinflammatory cytokines. In mice, Toll-like receptor 2 (TLR2) and TLR9 as well as intracellular nucleotide-sensing pathways have been shown to recognize herpe...

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Bibliographic Details
Main Authors: Melchjorsen, Jesper, Rintahaka, Johanna, Søby, Stine, Horan, Kristy A., Poltajainen, Alina, Østergaard, Lars, Paludan, Søren R., Matikainen, Sampsa
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953193/
https://ncbi.nlm.nih.gov/pubmed/20739519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01106-10
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