Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors()

The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN responses. It is known that plasmacytoid dendritic cells sense herpesvirus DNA in endosomes via TLR9, and that non-immune tissue cells can sense herp...

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書誌詳細
主要な著者: Horan, Kristy A., Hansen, Kathrine, Jakobsen, Martin R., Holm, Christian K., Søby, Stine, Unterholzner, Leonie, Thompson, Mikayla, West, John A., Iversen, Marie B., Rasmussen, Simon B., Ellermann-Eriksen, Svend, Kurt-Jones, Evelyn, Landolfo, Santo, Damania, Blossom, Melchjorsen, Jesper, Bowie, Andrew G., Fitzgerald, Katherine A., Paludan, Søren R.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578088/
https://ncbi.nlm.nih.gov/pubmed/23345332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202749
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