Toll-like Receptor-8 Agonistic Activities in C2, C4, and C8 Modified Thiazolo[4,5-c]quinolines

Toll-like receptor (TLR)-8 agonists typified by the 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) chemotype are uniquely potent in activating adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds could be promising candidat...

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Main Authors: Kokatla, Hari Prasad, Yoo, Euna, Salunke, Deepak B., Sil, Diptesh, Ng, Cameron F., Balakrishna, Rajalakshmi, Malladi, Subbalakshmi S., Fox, Lauren M., David, Sunil A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577938/
https://ncbi.nlm.nih.gov/pubmed/23314908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob26705e
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