Integration of HPV6 and Downregulation of AKR1C3 Expression Mark Malignant Transformation in a Patient with Juvenile-Onset Laryngeal Papillomatosis

Juvenile-onset recurrent respiratory papillomatosis (RRP) is associated with low risk human papillomavirus (HPV) types 6 and 11. Malignant transformation has been reported solely for HPV11-associated RRP in 2–4% of all RRP-cases, but not for HPV6. The molecular mechanisms in the carcinogenesis of lo...

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Main Authors: Huebbers, Christian Ulrich, Preuss, Simon Florian, Kolligs, Jutta, Vent, Julia, Stenner, Markus, Wieland, Ulrike, Silling, Steffi, Drebber, Uta, Speel, Ernst-Jan M., Klussmann, Jens Peter
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577740/
https://ncbi.nlm.nih.gov/pubmed/23437342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057207
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