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The Role of Tyrosine 71 in Modulating the Flap Conformations of BACE1
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a potential target for treating Alzheimer’s disease. BACE1’s binding site is partially covered by a flexible loop on its N-terminal domain, known as the “flap,” which has been found in several conformations in crystal structures of BACE1...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3577374/ https://ncbi.nlm.nih.gov/pubmed/21590744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23050 |
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