Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells

Hematopoietic stem cells (HSC) and an earlier wave of definitive erythroid/myeloid progenitors (EMPs) differentiate from hemogenic endothelial cells in the conceptus. EMPs can be generated in vitro from embryonic or induced pluripotent stem cells, but efforts to produce HSCs have largely failed. The...

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Main Authors: Chen, Michael J., Li, Yan, De Obaldia, Maria Elena, Yang, Qi, Yzaguirre, Amanda D., Yamada-Inagawa, Tomoko, Vink, Chris S., Bhandoola, Avinash, Dzierzak, Elaine, Speck, Nancy A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576591/
https://ncbi.nlm.nih.gov/pubmed/22136929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.10.003
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