Single-Molecule Imaging Reveals Aβ42:Aβ40 Ratio-Dependent Oligomer Growth on Neuronal Processes

Soluble oligomers of the amyloid-β peptide have been implicated as proximal neurotoxins in Alzheimer’s disease. However, the identity of the neurotoxic aggregate(s) and the mechanisms by which these species induce neuronal dysfunction remain uncertain. Physiologically relevant experimentation is hin...

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Autors principals: Johnson, Robin D., Schauerte, Joseph A., Chang, Chun-Chieh, Wisser, Kathleen C., Althaus, John Christian, Carruthers, Cynthia J.L., Sutton, Michael A., Steel, Duncan G., Gafni, Ari
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576537/
https://ncbi.nlm.nih.gov/pubmed/23442968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.12.051
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