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Mouse Zygotes Respond to Severe Sperm DNA Damage by Delaying Paternal DNA Replication and Embryonic Development

Mouse zygotes do not activate apoptosis in response to DNA damage. We previously reported a unique form of inducible sperm DNA damage termed sperm chromatin fragmentation (SCF). SCF mirrors some aspects of somatic cell apoptosis in that the DNA degradation is mediated by reversible double strand bre...

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Bibliografiske detaljer
Main Authors: Gawecka, Joanna E., Marh, Joel, Ortega, Michael, Yamauchi, Yasuhiro, Ward, Monika A., Ward, W. Steven
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576397/
https://ncbi.nlm.nih.gov/pubmed/23431372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056385
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