Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis

The ErbB2 and TGFβ signaling pathways cooperate to promote the migratory, invasive, and metastatic behavior of breast cancer cells. We previously demonstrated that ShcA is necessary for these synergistic interactions. Through a structure/function approach, we now show that the phosphotyrosine-bindin...

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Autors principals: Northey, Jason J., Dong, Zhifeng, Ngan, Elaine, Kaplan, Andrew, Hardy, W. Rod, Pawson, Tony, Siegel, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576125/
https://ncbi.nlm.nih.gov/pubmed/23277357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424804
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