The Trithorax Group Protein Ash2l Is Essential for Pluripotency and Maintaining Open Chromatin in Embryonic Stem Cells

Embryonic stem (ES) cells exhibit general characteristics of open chromatin, a state that may be necessary for ES cells to efficiently self-renew while remaining poised for differentiation. Histone H3K4 and H3K9 trimethylation associate as a general rule, with open and silenced chromatin, respective...

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Bibliographic Details
Main Authors: Wan, Ma, Liang, Jiancong, Xiong, Yuanyan, Shi, Fengtao, Zhang, Yi, Lu, Weisi, He, Quanyuan, Yang, Dong, Chen, Rui, Liu, Dan, Barton, Michelle, Songyang, Zhou
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576105/
https://ncbi.nlm.nih.gov/pubmed/23239880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424515
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