Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; the relationship between these two activities is unclear. Here we identify a RNA binding pocket on WDR5, and discover a WDR5 mutant (F266A) that selectively abrogates RNA binding without affecting MLL complex assembly or...

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Detalhes bibliográficos
Main Authors: Yang, Yul W, Flynn, Ryan A, Chen, Yong, Qu, Kun, Wan, Bingbing, Wang, Kevin C, Lei, Ming, Chang, Howard Y
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921674/
https://ncbi.nlm.nih.gov/pubmed/24521543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02046
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