Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

Ceramide is a key intermediate in the pathway of sphingolipid biosynthesis and is an important intracellular messenger. We recently generated a ceramide synthase 2 (CerS2) null mouse that cannot synthesize very long acyl chain (C22-C24) ceramides. This mouse displays severe and progressive hepatopat...

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Hlavní autoři: Zigdon, Hila, Kogot-Levin, Aviram, Park, Joo-Won, Goldschmidt, Ruth, Kelly, Samuel, Merrill, Alfred H., Scherz, Avigdor, Pewzner-Jung, Yael, Saada, Ann, Futerman, Anthony H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576098/
https://ncbi.nlm.nih.gov/pubmed/23283968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402719
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