Encephalopathy Caused by Ablation of Very Long Acyl Chain Ceramide Synthesis May Be Largely Due to Reduced Galactosylceramide Levels

Sphingolipids (SLs) act as signaling molecules and as structural components in both neuronal cells and myelin. We now characterize the biochemical, histological, and behavioral abnormalities in the brain of a mouse lacking very long acyl (C22–C24) chain SLs. This mouse, which is defective in the abi...

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Main Authors: Ben-David, Oshrit, Pewzner-Jung, Yael, Brenner, Ori, Laviad, Elad L., Kogot-Levin, Aviram, Weissberg, Itai, Biton, Inbal E., Pienik, Reut, Wang, Elaine, Kelly, Samuel, Alroy, Joseph, Raas-Rothschild, Annick, Friedman, Alon, Brügger, Britta, Merrill, Alfred H., Futerman, Anthony H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191043/
https://ncbi.nlm.nih.gov/pubmed/21705317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261206
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