Protection of a Ceramide Synthase 2 Null Mouse from Drug-induced Liver Injury: ROLE OF GAP JUNCTION DYSFUNCTION AND CONNEXIN 32 MISLOCALIZATION

Very long chain (C22-C24) ceramides are synthesized by ceramide synthase 2 (CerS2). A CerS2 null mouse displays hepatopathy because of depletion of C22-C24 ceramides, elevation of C16-ceramide, and/or elevation of sphinganine. Unexpectedly, CerS2 null mice were resistant to acetaminophen-induced hep...

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Bibliografische gegevens
Hoofdauteurs: Park, Woo-Jae, Park, Joo-Won, Erez-Roman, Racheli, Kogot-Levin, Aviram, Bame, Jessica R., Tirosh, Boaz, Saada, Ann, Merrill, Alfred H., Pewzner-Jung, Yael, Futerman, Anthony H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Lipids
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829405/
https://ncbi.nlm.nih.gov/pubmed/24019516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448852
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