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Proton Sensors in the Pore Domain of the Cardiac Voltage-gated Sodium Channel

Protons impart isoform-specific modulation of inactivation in neuronal, skeletal muscle, and cardiac voltage-gated sodium (Na(V)) channels. Although the structural basis of proton block in Na(V) channels has been well described, the amino acid residues responsible for the changes in Na(V) kinetics d...

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Autores principales: Jones, David K., Peters, Colin H., Allard, Charlene R., Claydon, Tom W., Ruben, Peter C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576083/
https://ncbi.nlm.nih.gov/pubmed/23283979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434266
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