Structural insight into the separate roles of inositol tetraphosphate and deacetylase-activating domain in activation of histone deacetylase 3

Histone deacetylases (HDACs) repress transcription by deacetylating acetyllysines on specific histone tails. HDAC3 is implicated in neurodegenerative diseases, certain leukemias, and even in disrupting HIV-1 latency. A recent crystal structure of HDAC3 in complex with the deacetylase-activating doma...

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Main Authors: Arrar, Mehrnoosh, Turnham, Rigney, Pierce, Levi, de Oliveira, Cesar Augusto F, McCammon, J Andrew
Formato: Artigo
Idioma:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575863/
https://ncbi.nlm.nih.gov/pubmed/23139175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2190
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