Structural insight into the separate roles of inositol tetraphosphate and deacetylase-activating domain in activation of histone deacetylase 3

Histone deacetylases (HDACs) repress transcription by deacetylating acetyllysines on specific histone tails. HDAC3 is implicated in neurodegenerative diseases, certain leukemias, and even in disrupting HIV-1 latency. A recent crystal structure of HDAC3 in complex with the deacetylase-activating doma...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Arrar, Mehrnoosh, Turnham, Rigney, Pierce, Levi, de Oliveira, Cesar Augusto F, McCammon, J Andrew
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley Subscription Services, Inc., A Wiley Company 2013
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575863/
https://ncbi.nlm.nih.gov/pubmed/23139175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2190
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk