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Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains
The RNA helicase Upf1 is a multifaceted eukaryotic enzyme involved in DNA replication, telomere metabolism and several mRNA degradation pathways. Upf1 plays a central role in nonsense-mediated mRNA decay (NMD), a surveillance process in which it links premature translation termination to mRNA degrad...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575847/ https://ncbi.nlm.nih.gov/pubmed/23275559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1320 |
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