Regulation of pluripotency and self-renewal of ES cells through epigenetic-threshold modulation and mRNA pruning

ES cell pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various transcription factors and chromatin modifying enzymes. How these factors coordinate with one another to maintain the bivalent chromatin state so that ES cells can undergo rapid self-renewa...

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Detalhes bibliográficos
Main Authors: Jia, Junling, Zheng, Xiaobin, Hu, Gangqing, Cui, Kairong, Zhang, Junqi, Zhang, Anying, Jiang, Hao, Lu, Bingwen, Yates, John, Liu, Chengyu, Zhao, Keji, Zheng, Yixian
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575637/
https://ncbi.nlm.nih.gov/pubmed/23101626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.023
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