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Regulation of pluripotency and self-renewal of ES cells through epigenetic-threshold modulation and mRNA pruning
ES cell pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various transcription factors and chromatin modifying enzymes. How these factors coordinate with one another to maintain the bivalent chromatin state so that ES cells can undergo rapid self-renewa...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575637/ https://ncbi.nlm.nih.gov/pubmed/23101626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.023 |
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