Hepatic Stellate Cells Preferentially Induce Foxp3(+) Regulatory T Cells by Production of Retinoic Acid

The liver has long been described as immunosuppressive, although the mechanisms underlying this phenomenon are incompletely understood. Hepatic stellate cells (HSCs), a population of liver nonparenchymal cells, are potent producers of the regulatory T cell (Treg)–polarizing molecules TGF-β1 and all-...

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Main Authors: Dunham, Richard M., Thapa, Manoj, Velazquez, Victoria M., Elrod, Elizabeth J., Denning, Timothy L., Pulendran, Bali, Grakoui, Arash
Format: Artigo
Jezik:Inglês
Izdano: AAI 2013
Teme:
Immune Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575565/
https://ncbi.nlm.nih.gov/pubmed/23359509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201937
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