Liver Fibrosis Occurs Through Dysregulation of MyD88-dependent Innate B cell Activity

Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote the profibrogenic activity of B cells. Fibrosis is completely attenuated in carbon tetrachloride (CCl(4))-treated B c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hepatology
Prif Awduron: Thapa, Manoj, Chinnadurai, Raghavan, Velazquez, Victoria M., Tedesco, Dana, Elrod, Elizabeth, Han, Jin-Hwan, Sharma, Prachi, Ibegbu, Chris, Gewirtz, Andrew, Anania, Frank, Pulendran, Bali, Suthar, Mehul S., Grakoui, Arash
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441566/
https://ncbi.nlm.nih.gov/pubmed/25711908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27761
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