Liver Fibrosis Occurs Through Dysregulation of MyD88-dependent Innate B cell Activity

Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote the profibrogenic activity of B cells. Fibrosis is completely attenuated in carbon tetrachloride (CCl(4))-treated B c...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Thapa, Manoj, Chinnadurai, Raghavan, Velazquez, Victoria M., Tedesco, Dana, Elrod, Elizabeth, Han, Jin-Hwan, Sharma, Prachi, Ibegbu, Chris, Gewirtz, Andrew, Anania, Frank, Pulendran, Bali, Suthar, Mehul S., Grakoui, Arash
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441566/
https://ncbi.nlm.nih.gov/pubmed/25711908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27761
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