Liver Fibrosis Occurs Through Dysregulation of MyD88-dependent Innate B cell Activity

Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote the profibrogenic activity of B cells. Fibrosis is completely attenuated in carbon tetrachloride (CCl(4))-treated B c...

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Publicat a:Hepatology
Autors principals: Thapa, Manoj, Chinnadurai, Raghavan, Velazquez, Victoria M., Tedesco, Dana, Elrod, Elizabeth, Han, Jin-Hwan, Sharma, Prachi, Ibegbu, Chris, Gewirtz, Andrew, Anania, Frank, Pulendran, Bali, Suthar, Mehul S., Grakoui, Arash
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441566/
https://ncbi.nlm.nih.gov/pubmed/25711908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27761
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