Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

BACKGROUND: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multi...

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Main Authors: Torres, Manuel, Jimenez, Sebastian, Sanchez-Varo, Raquel, Navarro, Victoria, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Carmona, Irene, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575255/
https://ncbi.nlm.nih.gov/pubmed/23173743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-59
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