Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

BACKGROUND: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Torres, Manuel, Jimenez, Sebastian, Sanchez-Varo, Raquel, Navarro, Victoria, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Carmona, Irene, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575255/
https://ncbi.nlm.nih.gov/pubmed/23173743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-59
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares